Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptors expressed on the surface of hematopoietic stem cells. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell line. Granulocyte-Colony Stimulating Factor induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. The synthesis of G-CSF can be induced by bacterial endotoxins, TNFalpha, Interleukin-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of G-CSF. In epithelial, endothelial, and fibroblastic cells, secretion of G-CSF is induced by Interleukin-17. rHu G-CSF produced in E. coli is a single, non-glycosylated, polypeptide chain that contains 175 amino acids and has a molecular mass of 18.8 KD.
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