Interferons (IFNs) are low molecular weight proteins that belong to the class of glycoproteins known as cytokines. Interferons are part of the non-specific immune system and are an important first line of defense against viral infections. Interferon-ß is known to affect many important cell mediated immune responses, including enhanced expression of MHC molecules, ß2-microglobulin, tumor associated antigens, and cytokine receptors for tumor necrosis factor, interleukin-1, interleukin-2, and colony stimulating factors. IFN-beta-1a is a potent endogenous inhibitor of angiogenesis. IFN-beta-1a is expressed in CHO cells.
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