Amazing Spider-Man (1963-1998) #3

Atomic scientist Dr. Otto Octavius was was given the name the name Doctor Octopus by his peers due to the four remote-controlled "arms" he had created. During an experiment, an explosion caused the arms to be fused to his body. He could now control the mechanical arms with his mind. Now on the verge of insanity, Dr. Octopus begins his criminal career.