Anti-HIV Bioadhesive Microencapsulated Vaginal Gel: Vaginal

Anti-HIV Bioadhesive Microencapsulated Vaginal Gel: Vaginal Bio adhesive Drug Delivery Systems
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The aim of this study was to develop and evaluate Zidovudine (AZT) loaded microparticulated bioadhesive vaginal gel (AZMBVG) in order to obtain a controlled-releasing, in order to obtain a controlled-release system for treatment of AIDS. AZT microparticle AZMCs was prepared by O/O single emulsion solvent evaporation method (II) and evaluated for encapsulation efficiency, drug loading, surface morphology and invitro drug release profiles and drug release mechanism and optimized. To achieve second objective, optimized AZMC4 were encompassed in bioadhesive gel to form AZMBVGs by cold mechanical method and compared with the bioadhesive vaginal gel (BVG1) without microcapsule. The optimized microcapsules were incorporated in bioadhesive gel prepared using different bioadhesive polymer evaluated the gel for the encapsulation efficiency, drug loading,invitro release profiles and drug release kinetics, spreadability, extrudibility, bioadhesion , vaginal irritancy and pharmacokinetics study by invivo methods by using New Zealand white female rabbit model. A comprehensive protocol, for the AZMBVG was developed successfully. Further research in this area will be significant outcome for AIDS
Country USA
Brand LAP Lambert Academic Publishing
Manufacturer LAP LAMBERT Academic Publishing
Binding Paperback
UnitCount 1
EANs 9783659149986
ReleaseDate 0000-00-00

Country	USA
Brand	LAP Lambert Academic Publishing
Manufacturer	LAP LAMBERT Academic Publishing
Binding	Paperback
UnitCount	1
EANs	9783659149986
ReleaseDate	0000-00-00

Anti-HIV Bioadhesive Microencapsulated Vaginal Gel: Vaginal Bio adhesive Drug Delivery Systems

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