False Hope: Bone Marrow Transplantation for Breast Cancer

False Hope: Bone Marrow Transplantation for Breast Cancer

In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones.

It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today.

Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.
Country USA
Brand OUP USA
Manufacturer Oxford University Press
Binding Hardcover
ItemPartNumber 5 line illustrations
UnitCount 1
EANs 9780195187762
ReleaseDate 0000-00-00

Country	USA
Brand	OUP USA
Manufacturer	Oxford University Press
Binding	Hardcover
ItemPartNumber	5 line illustrations
UnitCount	1
EANs	9780195187762
ReleaseDate	0000-00-00

False Hope: Bone Marrow Transplantation for Breast Cancer

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