Histologic Examination of Host-Parasite Interactions Fundulus

Histologic Examination of Host-Parasite Interactions Fundulus grandis: Examining the cellular immune response in the gulf killifish to nematode parasites found within the mesenteries

Little is known about the immunobiology of fish responses to parasitic infections. The aim of this study was to describe a model for fish-nematode interactions on the immunological front, and to develop new reagents for the study of this model. Gulf killifish, Fundulus grandis, were collected over two seasons from MS, USA, and examined for endoparasites, particularly the larval nematode Eustrongylides ignotus. A baseline study was preformed to determine the prevalence, intensity, and histologic features of E. ignotus infection in F. grandis. In addition, two monoclonal antibodies, (mAb) M24-2 and 2C11, were characterized for their use in this project, as well as for general applications in fish immunobiology. mAb M24-2 was developed and found to recognize a ~ 14.5 kD protein in serum from all fish tested, and recognizes hen egg lysozyme (HEL). mAb 2C11 was developed and determined to recognize a ~17 kD protein found in fish cell lysates, but in not plasma. It was determined that mAb 2C11 recognizes granule content of a small population of highly granulated cells, most likely eosinophilic granular cells (EGCs). Like mAb M24-2, mAb 2C11 was found to be cross reactive in other fish.
Country USA
Brand VDM Verlag
Manufacturer Scholars' Press
Binding Paperback
ItemPartNumber black & white illustrations
ReleaseDate 2015-07-22
UnitCount 1
EANs 9783639766592

Country	USA
Brand	VDM Verlag
Manufacturer	Scholars' Press
Binding	Paperback
ItemPartNumber	black & white illustrations
ReleaseDate	2015-07-22
UnitCount	1
EANs	9783639766592

Histologic Examination of Host-Parasite Interactions Fundulus grandis: Examining the cellular immune response in the gulf killifish to nematode parasites found within the mesenteries

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