Nitrates Updated: Current Use in Angina, Ischemia, Infarction

Nitrates Updated: Current Use in Angina, Ischemia, Infarction and Failure

Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can reÂ lieve pain in angina pectoris has been known at least since 1867, when Lauder Brunton described their clinical use. Now, almost 130 years later, we are constantly learning more about their optimal use in anginal syndromes. For example, there is no doubt that nitrate tolerance occurs, but equally no doubt that certain drug dosages help to attenuate such tolerÂ ance. Thus, our understanding of nitrate tolerance has been taken further by the advent of new nitrate preparations and by studies at a basic science level. The current intense interest in nitrates has been rekindled by the growing emphasis on the role of the endothelium in the production of nitric oxide, a basic cardiovascular regulator. If nitric oxide is vasodilator and protects the vascular endothelium, then nitrates should also have similar properties. Hence this book starts off with the role of the endothelium and niÂ trates in vasodilation. Next, the mechanisms of acÂ tion of nitrates are considered with emphasis on the role of cyclic GMP. The chief limitation to the use of nitrates lies in nitrate tolerance. After carefully looking at all the evidence, the authors of the third chapter conclude that the mechanism is likely to be multifactorial. The mechanism responsible for the tolerance still remains unknown. In vitro tolerance may be due to enhanced production of vascular superoxide [1].
Country USA
Brand Springer
Manufacturer Springer
Binding Paperback
ItemPartNumber Refer to Sapnet.
ReleaseDate 1997-01-31
UnitCount 1
EANs 9780792334668

Country	USA
Brand	Springer
Manufacturer	Springer
Binding	Paperback
ItemPartNumber	Refer to Sapnet.
ReleaseDate	1997-01-31
UnitCount	1
EANs	9780792334668

Nitrates Updated: Current Use in Angina, Ischemia, Infarction and Failure

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