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Industrial & Scientific > Lab & Scientific Products > Life Science Supplies > Biomolecules > Antibodies > B00ZIYP7GU
  1. Rabbit Anti-P53 protein(wt-p53) Polyclonal Antibody, 1ug/ul
    Image(s) provided for illustrative purposes and may differ from the actual product
  2. Rabbit Anti-P53 protein(wt-p53) Polyclonal Antibody, 1ug/ul

    Delivery: 10-20 Working Days
    Sold Out / Out of Stock

Product Description

  • KLH conjugated synthetic peptide derived from human P53
  • Aqueous buffered containing 100ug/ml BSA, 50% glycerol and 0.09% NaN3. Store at -20°C for 12 months.
  • Human, Mouse, Rat
  • WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
  • P53; BCC7; LFS1; TRP53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53;
Additional Information

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.


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